InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COX18

Summary

InnateDB Protein

IDBP-23260.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COX18

Protein Name

COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295890

InnateDB Gene

IDBG-23258 (COX18)

Protein Structure

UniProt Annotation

Function

Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space. {ECO:0000269PubMed:16911509}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:16212937}; Multi-pass membrane protein {ECO:0000269PubMed:16212937}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008565	protein transporter activity

Biological Process

GO:0008535	respiratory chain complex IV assembly
GO:0015031	protein transport
GO:0051204	protein insertion into mitochondrial membrane
GO:0051205	protein insertion into membrane