InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMPRSS2

Summary

InnateDB Protein

IDBP-232716.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMPRSS2

Protein Name

transmembrane protease, serine 2

Synonyms

PP9284; PRSS10;

Species

Homo sapiens

Ensembl Protein

ENSP00000381588

InnateDB Gene

IDBG-3965 (TMPRSS2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006898	receptor-mediated endocytosis
GO:0016540	protein autoprocessing
GO:0046598	positive regulation of viral entry into host cell

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001190 SRCR domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
IPR017448 SRCR-like domain

PFAM

PF00530
PF00089
PF00057
PF09342

PRINTS

PR00258
PR00722
PR00261

PIRSF

SMART

SM00020
SM00192
SM00202

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt