InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB1A

Summary

InnateDB Protein

IDBP-232867.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB1A

Protein Name

RAB1A, member RAS oncogene family

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000381540

InnateDB Gene

IDBG-54165 (RAB1A)

Protein Structure

UniProt Annotation

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport. {ECO:0000269PubMed:20639577, ECO:0000269PubMed:20861236, ECO:0000269PubMed:21303926, ECO:0000269PubMed:22939626}.

Subcellular Localization

Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome {ECO:0000250}. Note=Alternates between membrane-associated and cytosolic forms.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000278	mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006897	endocytosis
GO:0006914	autophagy
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0016477	cell migration
GO:0030252	growth hormone secretion
GO:0042742	defense response to bacterium
GO:0047496	vesicle transport along microtubule
GO:0072606	interleukin-8 secretion

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF08477

PRINTS

PR00449

PIRSF

SMART

SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt