Version 5.4
Homo sapiens Protein: PLEKHB1
Summary
InnateDB Protein IDBP-232942.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHB1
Protein Name pleckstrin homology domain containing, family B (evectins) member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381507
InnateDB Gene IDBG-63848 (PLEKHB1)
Protein Structure
UniProt Annotation
Function Required for proper localization of retinogeniculate projections but not for eye-specific segregation. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000269PubMed:10585447}. Cytoplasm {ECO:0000250}. Note=Localizes to the apical juxta- nuclear Golgi region of the cytoplasm (By similarity). Membrane- associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in retina and brain. Levels are very low or not detectable in all other tissues tested. {ECO:0000269PubMed:10585447}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007602 phototransduction
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UF11
PhosphoSite PhosphoSite-Q9UF11
TrEMBL F5H190
UniProt Splice Variant
Entrez Gene 58473
UniGene Hs.445489
RefSeq NP_001123506
HUGO HGNC:19079
OMIM 607651
CCDS CCDS44674
HPRD 09630
IMGT
EMBL AF081583 AF093249 AF100612 AF101054 AK289620 AK289909 AK290109 AK301299 AK314748 AP000860 AP002993 BC008075 CH471076 U89715
GenPept AAF16675 AAF16684 AAF18572 AAF18932 AAF21786 AAH08075 BAF82309 BAF82598 BAF82798 BAG37288 BAH13452 EAW74900 EAW74903 EAW74904

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca