InnateDB Protein
|
IDBP-232944.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PLEKHB1
|
Protein Name
|
pleckstrin homology domain containing, family B (evectins) member 1
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000381505
|
InnateDB Gene
|
IDBG-63848 (PLEKHB1)
|
Protein Structure
|
|
Function |
Required for proper localization of retinogeniculate projections but not for eye-specific segregation. {ECO:0000250}.
|
Subcellular Localization |
Membrane {ECO:0000269PubMed:10585447}. Cytoplasm {ECO:0000250}. Note=Localizes to the apical juxta- nuclear Golgi region of the cytoplasm (By similarity). Membrane- associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in retina and brain. Levels are very low or not detectable in all other tissues tested. {ECO:0000269PubMed:10585447}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
2
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001849
Pleckstrin homology domain
|
PFAM |
PF00169
|
PRINTS |
|
PIRSF |
|
SMART |
SM00233
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9UF11
|
PhosphoSite |
PhosphoSite-Q9UF11
|
TrEMBL |
F5H866
|
UniProt Splice Variant |
|
Entrez Gene |
58473
|
UniGene |
Hs.445489
|
RefSeq |
NP_001123505
|
HUGO |
HGNC:19079
|
OMIM |
607651
|
CCDS |
CCDS44673
|
HPRD |
09630
|
IMGT |
|
EMBL |
AF081583
AF093249
AF100612
AF101054
AK289620
AK289909
AK290109
AK301299
AK314748
AP000860
AP002993
BC008075
CH471076
U89715
|
GenPept |
AAF16675
AAF16684
AAF18572
AAF18932
AAF21786
AAH08075
BAF82309
BAF82598
BAF82798
BAG37288
BAH13452
EAW74900
EAW74901
EAW74903
EAW74904
EAW74905
EAW74906
|
|
|