InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FCER2

Summary

InnateDB Protein

IDBP-23318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCER2

Protein Name

Fc fragment of IgE, low affinity II, receptor for (CD23)

Synonyms

BLAST-2; CD23; CD23A; CLEC4J; FCE2; IGEBF;

Species

Homo sapiens

Ensembl Protein

ENSP00000264072

InnateDB Gene

IDBG-23316 (FCER2)

Protein Structure

UniProt Annotation

Function

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Subcellular Localization

Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	6 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0019863	IgE binding
GO:0030246	carbohydrate binding
GO:0046872	metal ion binding

Biological Process

GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0007219	Notch signaling pathway
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051712	positive regulation of killing of cells of other organism
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0070062	extracellular vesicular exosome