InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CGGBP1

Summary

InnateDB Protein

IDBP-233184.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CGGBP1

Protein Name

CGG triplet repeat binding protein 1

Synonyms

CGGBP; p20-CGGBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000381429

InnateDB Gene

IDBG-115757 (CGGBP1)

Protein Structure

UniProt Annotation

Function

Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. {ECO:0000269PubMed:9201980}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9201980}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in placenta, thymus, lymph nodes, cerebellum and cerebral cortex. Low expression in other regions of the brain. {ECO:0000269PubMed:14667814}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003690	double-stranded DNA binding