Version 5.4
Homo sapiens Protein: PDE9A
Summary
InnateDB Protein IDBP-233311.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE9A
Protein Name phosphodiesterase 9A
Synonyms HSPDE9A2;
Species Homo sapiens
Ensembl Protein ENSP00000381291
InnateDB Gene IDBG-4450 (PDE9A)
Protein Structure
UniProt Annotation
Function Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. {ECO:0000269PubMed:18757755}.
Subcellular Localization Isoform PDE9A1: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus. Endoplasmic reticulum.Isoform PDE9A2: Cell projection, ruffle membrane. Cytoplasm, perinuclear region.Isoform PDE9A3: Cytoplasm. Endoplasmic reticulum.Isoform PDE9A17: Cytoplasm. Endoplasmic reticulum.
Disease Associations
Tissue Specificity Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate. {ECO:0000269PubMed:12565835}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0008152 metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0032587 ruffle membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase
PFAM PF00233
PRINTS PR00387
PIRSF
SMART SM00471
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O76083
PhosphoSite PhosphoSite-O76083
TrEMBL
UniProt Splice Variant
Entrez Gene 5152
UniGene Hs.602634
RefSeq NP_001001574
HUGO HGNC:8795
OMIM 602973
CCDS CCDS42941
HPRD 09115
IMGT
EMBL AB017602 AF048837 AF067223 AF067224 AF067225 AF067226 AK294112 AK314679 AP001747 AY196299 AY196300 AY196301 AY196302 AY196303 AY196304 AY196305 AY196306 AY196307 AY196308 AY196309 AY196310 AY196311 AY196312 AY196313 AY196314 AY242121 AY701187 BC009047 BT007016 CH471079
GenPept AAC26723 AAC26724 AAC26725 AAC26726 AAC39778 AAH09047 AAO34685 AAO34686 AAO34687 AAO34688 AAO34689 AAO34690 AAO34691 AAO34692 AAO34693 AAO34694 AAO34695 AAO34696 AAO34697 AAO34698 AAO34699 AAO34700 AAO88210 AAP35662 AAV84271 BAA88847 BAA95552 BAG37232 BAG57446 EAX09536 EAX09537 EAX09540 EAX09541 EAX09542 EAX09544 EAX09546 EAX09548 EAX09549

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca