Version 5.4
Homo sapiens Gene: PDE9A
Summary
InnateDB Gene IDBG-4450.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE9A
Gene Name phosphodiesterase 9A
Synonyms HSPDE9A2
Species Homo sapiens
Ensembl Gene ENSG00000160191
Encoded Proteins
IDBP-4452
phosphodiesterase 9A
IDBP-4454
phosphodiesterase 9A
IDBP-4456
phosphodiesterase 9A
IDBP-4458
phosphodiesterase 9A
IDBP-4460
phosphodiesterase 9A
IDBP-4462
phosphodiesterase 9A
IDBP-233311
phosphodiesterase 9A
IDBP-233313
phosphodiesterase 9A
IDBP-233315
phosphodiesterase 9A
IDBP-233317
phosphodiesterase 9A
IDBP-233319
phosphodiesterase 9A
IDBP-233321
phosphodiesterase 9A
IDBP-233323
phosphodiesterase 9A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:42653636-42775509
Strand Forward strand
Band q22.3
Transcripts
ENST00000291539 ENSP00000291539
ENST00000328862 ENSP00000328699
ENST00000380328 ENSP00000369685
ENST00000335512 ENSP00000335242
ENST00000335440 ENSP00000335365
ENST00000349112 ENSP00000344730
ENST00000398236 ENSP00000381291
ENST00000398234 ENSP00000381289
ENST00000398232 ENSP00000381287
ENST00000398229 ENSP00000381285
ENST00000398227 ENSP00000381283
ENST00000398225 ENSP00000381281
ENST00000398224 ENSP00000381280
ENST00000460905
ENST00000472401
ENST00000470987
ENST00000490803
ENST00000495521
ENST00000462571
ENST00000468805
ENST00000497805
ENST00000460989
ENST00000467403
ENST00000486902
ENST00000467162
ENST00000495343
ENST00000489319
ENST00000466472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0019934 cGMP-mediated signaling
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0032587 ruffle membrane
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041119
View Gene Order
ENSBTAG00000021899
Not yet available
Pathways
NETPATH
REACTOME
REACT_23767
cGMP effects pathway
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_604
Hemostasis pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.473927 Hs.602634
RefSeq NM_001001567 NM_001001568 NM_001001569 NM_001001570 NM_001001571 NM_001001572 NM_001001573 NM_001001574 NM_001001575 NM_001001576 NM_001001577 NM_001001578 NM_001001579 NM_001001580 NM_001001581 NM_001001582 NM_001001583 NM_001001584 NM_001001585 NM_002606
HUGO
OMIM
CCDS CCDS13690 CCDS33567 CCDS33568 CCDS33569 CCDS33570 CCDS33571 CCDS42941 CCDS42942 CCDS42943 CCDS42944 CCDS42945 CCDS42946 CCDS42947
HPRD 09115
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca