Version 5.4
Homo sapiens Protein: CMAS
Summary
InnateDB Protein IDBP-23333.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CMAS
Protein Name cytidine monophosphate N-acetylneuraminic acid synthetase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000229329
InnateDB Gene IDBG-23331 (CMAS)
Protein Structure
UniProt Annotation
Function Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
Subcellular Localization Nucleus {ECO:0000269PubMed:11602804}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Expressed in pancreas, kidney, liver, skeletal muscle, lung, placenta, brain, heart, colon, PBL, small intestine, ovary, testis, prostate, thymus and spleen. {ECO:0000269PubMed:11602804}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008781 N-acylneuraminate cytidylyltransferase activity
Biological Process
GO:0006054 N-acetylneuraminate metabolic process
GO:0009103 lipopolysaccharide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003329 Acylneuraminate cytidylyltransferase
IPR023214 HAD-like domain
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF02348
PF00702
PF08282
PF13419
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NFW8
PhosphoSite PhosphoSite-Q8NFW8
TrEMBL F5GYM0
UniProt Splice Variant
Entrez Gene 55907
UniGene
RefSeq NP_061156
HUGO HGNC:18290
OMIM 603316
CCDS CCDS8696
HPRD 04501
IMGT
EMBL AC007671 AC092862 AF271388 AF397212 AK022927 AL832975 BC016609
GenPept AAF76203 AAH16609 AAM90580 BAB14311 CAH56346

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca