Version 5.4
Homo sapiens Gene: CMAS
Summary
InnateDB Gene IDBG-23331.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CMAS
Gene Name cytidine monophosphate N-acetylneuraminic acid synthetase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111726
Encoded Proteins
IDBP-23333
cytidine monophosphate N-acetylneuraminic acid synthetase
IDBP-596035
cytidine monophosphate N-acetylneuraminic acid synthetase
IDBP-598326
cytidine monophosphate N-acetylneuraminic acid synthetase
IDBP-603007
cytidine monophosphate N-acetylneuraminic acid synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sialic acids are a family of nine-carbon sugars on cell surface glycoproteins and glycolipids that play a pivotal role in determining the structure and function of many animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development and N-glycosylation is a common post-translational modification during cellular differentiation. Sialic acids play important roles in cell-cell communications and immune responses. Sialylated glycoprotein and glycolipid formation requires the activation of a sialic acid to a cytidine monophosphate (CMP) diester by the enzyme encoded by this gene: CMP-N-acetylneuraminic acid synthetase. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:22046174-22065674
Strand Forward strand
Band p12.1
Transcripts
ENST00000229329 ENSP00000229329
ENST00000534981 ENSP00000446239
ENST00000535610 ENSP00000439404
ENST00000538498 ENSP00000440605
ENST00000537658
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008781 N-acylneuraminate cytidylyltransferase activity
Biological Process
GO:0006054 N-acetylneuraminate metabolic process
GO:0009103 lipopolysaccharide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030282
View Gene Order
ENSBTAG00000010136
Not yet available
Pathways
NETPATH
REACTOME
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_200874
Sialic acid metabolism pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
INOH
INOH website
Aminosugars metabolism pathway
PID NCI
Cross-References
SwissProt Q8NFW8
TrEMBL F5GYM0 F5H296
UniProt Splice Variant
Entrez Gene 55907
UniGene
RefSeq NM_018686
HUGO HGNC:18290
OMIM 603316
CCDS CCDS8696
HPRD
IMGT
EMBL AC007671 AC092862 AF271388 AF397212 AK022927 AL832975 BC016609
GenPept AAF76203 AAH16609 AAM90580 BAB14311 CAH56346
RNA Seq Atlas 55907

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca