InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GGH

Summary

InnateDB Protein

IDBP-23339.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GGH

Protein Name

gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)

Synonyms

GH;

Species

Homo sapiens

Ensembl Protein

ENSP00000260118

InnateDB Gene

IDBG-23337 (GGH)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.

Subcellular Localization

Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	13 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008238	exopeptidase activity
GO:0008242	omega peptidase activity
GO:0016787	hydrolase activity
GO:0034722	gamma-glutamyl-peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006541	glutamine metabolic process
GO:0010043	response to zinc ion
GO:0032868	response to insulin
GO:0042493	response to drug
GO:0045471	response to ethanol