Version 5.4
Homo sapiens Gene: GGH
Summary
InnateDB Gene IDBG-23337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGH
Gene Name gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Synonyms GH
Species Homo sapiens
Ensembl Gene ENSG00000137563
Encoded Proteins
IDBP-23339
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:63015079-63039171
Strand Reverse strand
Band q12.3
Transcripts
ENST00000260118 ENSP00000260118
ENST00000518466
ENST00000522852
ENST00000520609
ENST00000518113
ENST00000518966
ENST00000523479
ENST00000523788
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 13 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008238 exopeptidase activity
GO:0008242 omega peptidase activity
GO:0016787 hydrolase activity
GO:0034722 gamma-glutamyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006541 glutamine metabolic process
GO:0010043 response to zinc ion
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0045471 response to ethanol
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005829 cytosol
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073987
View Gene Order
ENSBTAG00000007534
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00790
Folate biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.78619
RefSeq NM_003878
HUGO
OMIM
CCDS CCDS6177
HPRD 03299
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca