InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NSF

Summary

InnateDB Protein

IDBP-233551.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NSF

Protein Name

N-ethylmaleimide-sensitive factor

Synonyms

SKD2;

Species

Homo sapiens

Ensembl Protein

ENSP00000381293

InnateDB Gene

IDBG-55627 (NSF)

Protein Structure

UniProt Annotation

Function

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	68 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0017075	syntaxin-1 binding
GO:0019901	protein kinase binding
GO:0019905	syntaxin binding
GO:0030165	PDZ domain binding
GO:0032403	protein complex binding
GO:0042623	ATPase activity, coupled
GO:0046872	metal ion binding

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0006200	ATP catabolic process
GO:0006813	potassium ion transport
GO:0006887	exocytosis
GO:0007268	synaptic transmission
GO:0015031	protein transport
GO:0045026	plasma membrane fusion

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003338 CDC48, N-terminal subdomain
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR004201 CDC48, domain 2
IPR009010 Aspartate decarboxylase-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029067 CDC48 domain 2-like

PFAM

PF02359
PF00004
PF07724
PF13304
PF02933

PRINTS

PIRSF

SMART

SM01073
SM00382
SM01072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P46459