InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VIMP

Summary

InnateDB Protein

IDBP-233586.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VIMP

Protein Name

Selenoprotein S

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000381282

InnateDB Gene

IDBG-32368 (VIMP)

Protein Structure

UniProt Annotation

Function

Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. {ECO:0000269PubMed:15215856}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008430	selenium binding
GO:0016209	antioxidant activity
GO:0019899	enzyme binding

Biological Process

GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus
GO:0006111	regulation of gluconeogenesis
GO:0006886	intracellular protein transport
GO:0006983	ER overload response
GO:0009749	response to glucose
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0030970	retrograde protein transport, ER to cytosol
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032869	cellular response to insulin stimulus
GO:0034599	cellular response to oxidative stress
GO:0045184	establishment of protein localization
GO:0045454	cell redox homeostasis
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0046325	negative regulation of glucose import
GO:0050728	negative regulation of inflammatory response
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process
GO:0051775	response to redox state
GO:0071222	cellular response to lipopolysaccharide
GO:0080164	regulation of nitric oxide metabolic process
GO:1902236	negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000110	negative regulation of macrophage apoptotic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle