Version 5.4
Homo sapiens Gene: VIMP
Summary
InnateDB Gene IDBG-32368.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VIMP
Gene Name VCP-interacting membrane protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131871
Encoded Proteins
IDBP-233586
Selenoprotein S
IDBP-596696
Selenoprotein S
IDBP-590652
Selenoprotein S
IDBP-598826
Selenoprotein S
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:101270817-101277500
Strand Reverse strand
Band q26.3
Transcripts
ENST00000398226 ENSP00000381282
ENST00000531964 ENSP00000433803
ENST00000526049 ENSP00000433541
ENST00000526043
ENST00000528346 ENSP00000434842
ENST00000527833
ENST00000529968
ENST00000534014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0008430 selenium binding
GO:0016209 antioxidant activity
GO:0019899 enzyme binding
Biological Process
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus
GO:0006111 regulation of gluconeogenesis
GO:0006886 intracellular protein transport
GO:0006983 ER overload response
GO:0009749 response to glucose
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0030970 retrograde protein transport, ER to cytosol
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032869 cellular response to insulin stimulus
GO:0034599 cellular response to oxidative stress
GO:0045184 establishment of protein localization
GO:0045454 cell redox homeostasis
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0046325 negative regulation of glucose import
GO:0050728 negative regulation of inflammatory response
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
GO:0051775 response to redox state
GO:0071222 cellular response to lipopolysaccharide
GO:0080164 regulation of nitric oxide metabolic process
GO:1902236 negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000110 negative regulation of macrophage apoptotic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005881 cytoplasmic microtubule
GO:0005886 plasma membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000075701
View Gene Order
ENSBTAG00000000640
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PN30
UniProt Splice Variant
Entrez Gene 55829
UniGene Hs.32148 Hs.681699
RefSeq NM_018445 NM_203472
HUGO HGNC:30396
OMIM 607918
CCDS CCDS53979
HPRD 12133
IMGT
EMBL AC023024
GenPept
RNA Seq Atlas 55829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca