InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOF

Summary

InnateDB Protein

IDBP-233694.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOF

Protein Name

apolipoprotein F

Synonyms

Apo-F; LTIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000381250

InnateDB Gene

IDBG-40996 (APOF)

Protein Structure

UniProt Annotation

Function

Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII. {ECO:0000269PubMed:9880564}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed by the liver and secreted in plasma. {ECO:0000269PubMed:8093033}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005319	lipid transporter activity
GO:0015485	cholesterol binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006869	lipid transport
GO:0008203	cholesterol metabolic process
GO:0033344	cholesterol efflux