Version 5.4
Homo sapiens Protein: TAC4
Summary
InnateDB Protein IDBP-233756.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAC4
Protein Name tachykinin 4 (hemokinin)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381221
InnateDB Gene IDBG-57869 (TAC4)
Protein Structure
UniProt Annotation
Function Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. {ECO:0000269PubMed:12716968, ECO:0000269PubMed:17101218, ECO:0000269PubMed:17437961, ECO:0000269PubMed:17655832}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta. {ECO:0000269PubMed:12716968, ECO:0000269PubMed:12788812}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0008217 regulation of blood pressure
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86UU9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 729220
UniGene Hs.652130
RefSeq NP_001070971
HUGO HGNC:16641
OMIM 607833
CCDS CCDS42359
HPRD 09701
IMGT
EMBL AF515828 AF515829 AF515830 AF515831 AF521560 AY471574 BC100840 BC100842 BC100843 CH471109
GenPept AAI00841 AAI00843 AAI00844 AAN77128 AAP30874 AAP30875 AAP30876 AAP30877 AAS46596 EAW94657

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca