Version 5.4
Homo sapiens Gene: TAC4
Summary
InnateDB Gene IDBG-57869.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAC4
Gene Name tachykinin 4 (hemokinin)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000176358
Encoded Proteins
IDBP-57871
tachykinin 4 (hemokinin)
IDBP-57873
tachykinin 4 (hemokinin)
IDBP-57875
tachykinin 4 (hemokinin)
IDBP-233756
tachykinin 4 (hemokinin)
IDBP-380879
tachykinin 4 (hemokinin)
IDBP-484854
tachykinin 4 (hemokinin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:49838309-49848017
Strand Reverse strand
Band q21.33
Transcripts
ENST00000334568 ENSP00000334042
ENST00000326219 ENSP00000325286
ENST00000352793 ENSP00000340461
ENST00000398154 ENSP00000381221
ENST00000436235 ENSP00000399702
ENST00000503603 ENSP00000421777
ENST00000608861
ENST00000608380
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
Biological Process
GO:0007217 tachykinin receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0046878 positive regulation of saliva secretion
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020872
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.652130
RefSeq NM_001077503 NM_001077504 NM_001077505 NM_001077506 NM_001242791 NM_170685
HUGO
OMIM
CCDS CCDS42357 CCDS42358 CCDS42359 CCDS42360 CCDS45727
HPRD 09701
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca