InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOP14

Summary

InnateDB Protein

IDBP-233911.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOP14

Protein Name

NOP14 nucleolar protein homolog (yeast)

Synonyms

C4orf9; NOL14; RES425; UTP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000381146

InnateDB Gene

IDBG-7779 (NOP14)

Protein Structure

UniProt Annotation

Function

Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019899	enzyme binding
GO:0030515	snoRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364	rRNA processing
GO:0042274	ribosomal small subunit biogenesis

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0030686	90S preribosome
GO:0030692	Noc4p-Nop14p complex
GO:0032040	small-subunit processome