Version 5.4
Homo sapiens Gene: NOP14
Summary
InnateDB Gene IDBG-7779.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOP14
Gene Name NOP14 nucleolar protein homolog (yeast)
Synonyms C4orf9; NOL14; RES425; UTP2
Species Homo sapiens
Ensembl Gene ENSG00000087269
Encoded Proteins
IDBP-7781
NOP14 nucleolar protein homolog (yeast)
IDBP-233911
NOP14 nucleolar protein homolog (yeast)
IDBP-361220
NOP14 nucleolar protein homolog (yeast)
IDBP-480244
NOP14 nucleolar protein homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NOP14 plays a role in the processing of the pre-18S rRNA and small ribosomal subunit assembly (Liu and Thiele, 2001 [PubMed 11694595]).[supplied by OMIM, Jun 2009]
This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:2937933-2963385
Strand Reverse strand
Band p16.3
Transcripts
ENST00000314262 ENSP00000315674
ENST00000398071 ENSP00000381146
ENST00000416614 ENSP00000405068
ENST00000507120
ENST00000502735 ENSP00000427415
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0019899 enzyme binding
GO:0030515 snoRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0030686 90S preribosome
GO:0030692 Noc4p-Nop14p complex
GO:0032040 small-subunit processome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036693
View Gene Order
ENSBTAG00000001504
Not yet available
Cross-References
SwissProt P78316
TrEMBL
UniProt Splice Variant
Entrez Gene 8602
UniGene Hs.627133
RefSeq NM_001291978 NM_001291979 NM_003703
HUGO HGNC:16821
OMIM 611526
CCDS CCDS33945
HPRD 12827
IMGT
EMBL AB000467 AF040965 BC026035 BC053635 CH471131
GenPept AAB97011 AAH26035 AAH53635 BAA19121 EAW82489 EAW82491 EAW82492
RNA Seq Atlas 8602

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca