InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SON

Summary

InnateDB Protein

IDBP-2340.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SON

Protein Name

SON DNA binding protein

Synonyms

BASS1; C21orf50; DBP-5; NREBP; SON3;

Species

Homo sapiens

Ensembl Protein

ENSP00000371095

InnateDB Gene

IDBG-2322 (SON)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. {ECO:0000269PubMed:20581448, ECO:0000269PubMed:21504830}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:1424986, ECO:0000269PubMed:21504830}. Note=Colocalizes with the pre-mRNA splicing factor SRSF2.

Disease Associations

Tissue Specificity

Widely expressed, with the higher expression seen in leukocyte and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	72 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000910	cytokinesis
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0043066	negative regulation of apoptotic process
GO:0043484	regulation of RNA splicing
GO:0051726	regulation of cell cycle