InnateDB Protein
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IDBP-234069.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SERPINB7
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Protein Name
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serpin peptidase inhibitor, clade B (ovalbumin), member 7
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Synonyms
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MEGSIN; PPKN; TP55;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000381101
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InnateDB Gene
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IDBG-4531 (SERPINB7)
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Protein Structure
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Function |
Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
Keratoderma, palmoplantar, Nagashima type (PPKN) [MIM:615598]: An autosomal recessive, non-syndromic, diffuse palmoplantar keratosis characterized by well-demarcated diffuse erythematous hyperkeratosis expanding onto the dorsal surfaces of the palms and feet and the Achilles tendon area. Hyperkeratosis is mild and non-progressive. {ECO:0000269PubMed:24207119}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Predominantly expressed in mesangial cells. Expressed in the epidermis of the whole body. {ECO:0000269PubMed:24207119}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004867
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serine-type endopeptidase inhibitor activity
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Biological Process |
GO:0010951
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negative regulation of endopeptidase activity
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GO:0030162
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regulation of proteolysis
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GO:0032914
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positive regulation of transforming growth factor beta1 production
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GO:0032967
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positive regulation of collagen biosynthetic process
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GO:0072126
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positive regulation of glomerular mesangial cell proliferation
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GO:0090362
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positive regulation of platelet-derived growth factor production
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Cellular Component |
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PDB ID |
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InterPro |
IPR023796
Serpin domain
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PFAM |
PF00079
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PRINTS |
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PIRSF |
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SMART |
SM00093
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TIGRFAMs |
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Modification |
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SwissProt |
O75635
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PhosphoSite |
PhosphoSite-O75635
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TrEMBL |
Q6MZG5
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UniProt Splice Variant |
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Entrez Gene |
8710
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UniGene |
Hs.742388
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RefSeq |
NP_003775
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HUGO |
HGNC:13902
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OMIM |
603357
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CCDS |
CCDS11988
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HPRD |
04524
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IMGT |
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EMBL |
AC069356
AC072051
AF027866
AK300828
BC069417
BC069442
BC069547
BC106743
BC106744
BX641156
D88575
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GenPept |
AAC64506
AAH69417
AAH69442
AAH69547
AAI06744
AAI06745
BAA31232
BAG62480
CAE46069
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