Version 5.4
Homo sapiens Gene: SERPINB7
Summary
InnateDB Gene IDBG-4531.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINB7
Gene Name serpin peptidase inhibitor, clade B (ovalbumin), member 7
Synonyms MEGSIN; PPKN; TP55
Species Homo sapiens
Ensembl Gene ENSG00000166396
Encoded Proteins
IDBP-4533
serpin peptidase inhibitor, clade B (ovalbumin), member 7
IDBP-234069
serpin peptidase inhibitor, clade B (ovalbumin), member 7
IDBP-372006
serpin peptidase inhibitor, clade B (ovalbumin), member 7
IDBP-372014
serpin peptidase inhibitor, clade B (ovalbumin), member 7
IDBP-372015
serpin peptidase inhibitor, clade B (ovalbumin), member 7
IDBP-589922
serpin peptidase inhibitor, clade B (ovalbumin), member 7
IDBP-584950
serpin peptidase inhibitor, clade B (ovalbumin), member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:63752935-63805376
Strand Forward strand
Band q21.33
Transcripts
ENST00000336429 ENSP00000337212
ENST00000398019 ENSP00000381101
ENST00000425392 ENSP00000397301
ENST00000447428 ENSP00000402362
ENST00000431370 ENSP00000393947
ENST00000540675 ENSP00000444572
ENST00000546027 ENSP00000444861
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0032967 positive regulation of collagen biosynthetic process
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0090362 positive regulation of platelet-derived growth factor production
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000067001
View Gene Order
ENSBTAG00000037773
Not yet available
Cross-References
SwissProt
TrEMBL C9JA68 C9JZR8
UniProt Splice Variant
Entrez Gene 8710
UniGene Hs.742388
RefSeq NM_001040147 NM_001261830 NM_001261831 NM_003784 XM_006722562
HUGO HGNC:13902
OMIM 603357
CCDS CCDS11988 CCDS58633
HPRD 04524
IMGT
EMBL AC069356 AC072051
GenPept
RNA Seq Atlas 8710

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca