InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANG

Summary

InnateDB Protein

IDBP-234138.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANG

Protein Name

angiogenin, ribonuclease, RNase A family, 5

Synonyms

ALS9; HEL168; RAA1; RNASE4; RNASE5;

Species

Homo sapiens

Ensembl Protein

ENSP00000381077

InnateDB Gene

IDBG-234136 (ANG)

Protein Structure

UniProt Annotation

Function

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. {ECO:0000269PubMed:12051708, ECO:0000269PubMed:1400510, ECO:0000269PubMed:19354288, ECO:0000269PubMed:21855800}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.

Disease Associations

Amyotrophic lateral sclerosis 9 (ALS9) [MIM:611895]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5- 10% of the cases. {ECO:0000269PubMed:15557516, ECO:0000269PubMed:16501576, ECO:0000269PubMed:17703939, ECO:0000269PubMed:17886298, ECO:0000269PubMed:18087731}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. {ECO:0000269PubMed:17886298, ECO:0000269PubMed:2440105}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003779	actin binding
GO:0004519	endonuclease activity
GO:0004540	ribonuclease activity
GO:0005102	receptor binding
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters
GO:0019843	rRNA binding
GO:0042277	peptide binding

Biological Process

GO:0001525	angiogenesis
GO:0001541	ovarian follicle development
GO:0001556	oocyte maturation
GO:0001666	response to hypoxia
GO:0001890	placenta development
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006651	diacylglycerol biosynthetic process
GO:0007154	cell communication
GO:0007202	activation of phospholipase C activity
GO:0008219	cell death
GO:0009303	rRNA transcription
GO:0009725	response to hormone
GO:0016477	cell migration
GO:0017148	negative regulation of translation
GO:0030041	actin filament polymerization
GO:0032148	activation of protein kinase B activity
GO:0032431	activation of phospholipase A2 activity
GO:0042327	positive regulation of phosphorylation
GO:0042592	homeostatic process
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050714	positive regulation of protein secretion
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005605	basal lamina
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0030426	growth cone
GO:0032311	angiogenin-PRI complex
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome