Version 5.4
Homo sapiens Gene: ANG
Summary
InnateDB Gene IDBG-234136.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANG
Gene Name angiogenin, ribonuclease, RNase A family, 5
Synonyms ALS9; HEL168; RAA1; RNASE4; RNASE5
Species Homo sapiens
Ensembl Gene ENSG00000214274
Encoded Proteins
IDBP-2345
angiogenin, ribonuclease, RNase A family, 5
IDBP-234138
angiogenin, ribonuclease, RNase A family, 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5\' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:20684177-20698971
Strand Forward strand
Band q11.2
Transcripts
ENST00000336811 ENSP00000336762
ENST00000397990 ENSP00000381077
ENST00000554073
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0004519 endonuclease activity
GO:0004540 ribonuclease activity
GO:0005102 receptor binding
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
GO:0019843 rRNA binding
GO:0042277 peptide binding
Biological Process
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001556 oocyte maturation
GO:0001666 response to hypoxia
GO:0001890 placenta development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006651 diacylglycerol biosynthetic process
GO:0007154 cell communication
GO:0007202 activation of phospholipase C activity
GO:0008219 cell death
GO:0009303 rRNA transcription
GO:0009725 response to hormone
GO:0016477 cell migration
GO:0017148 negative regulation of translation
GO:0030041 actin filament polymerization
GO:0032148 activation of protein kinase B activity
GO:0032431 activation of phospholipase A2 activity
GO:0042327 positive regulation of phosphorylation
GO:0042592 homeostatic process
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005605 basal lamina
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0030426 growth cone
GO:0032311 angiogenin-PRI complex
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000072115
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743472
RefSeq NM_001097577 NM_001145
HUGO
OMIM
CCDS CCDS9554
HPRD 00105
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca