InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BHLHE22

Summary

InnateDB Protein

IDBP-23427.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BHLHE22

Protein Name

basic helix-loop-helix family, member e22

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000318799

InnateDB Gene

IDBG-23425 (BHLHE22)

Protein Structure

UniProt Annotation

Function

Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Brain-specific, with the highest expression in the cerebellum. {ECO:0000269PubMed:12213201}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0021540	corpus callosum morphogenesis
GO:0021796	cerebral cortex regionalization
GO:0021952	central nervous system projection neuron axonogenesis
GO:0021957	corticospinal tract morphogenesis
GO:0021960	anterior commissure morphogenesis
GO:0030182	neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060040	retinal bipolar neuron differentiation
GO:0060042	retina morphogenesis in camera-type eye