Version 5.4
Homo sapiens Gene: BHLHE22
Summary
InnateDB Gene IDBG-23425.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BHLHE22
Gene Name basic helix-loop-helix family, member e22
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000180828
Encoded Proteins
IDBP-23427
basic helix-loop-helix family, member e22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary BHLHE22 belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. These proteins function as dimers and bind to an E-box DNA sequence (CANNTG). BHLHE22 is expressed exclusively in the central nervous system and retina (Xu et al., 2002 [PubMed 12213201]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:64580367-64583628
Strand Forward strand
Band q12.3
Transcripts
ENST00000321870 ENSP00000318799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0021540 corpus callosum morphogenesis
GO:0021796 cerebral cortex regionalization
GO:0021952 central nervous system projection neuron axonogenesis
GO:0021957 corticospinal tract morphogenesis
GO:0021960 anterior commissure morphogenesis
GO:0030182 neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060040 retinal bipolar neuron differentiation
GO:0060042 retina morphogenesis in camera-type eye
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025128
View Gene Order
ENSBTAG00000033173
Not yet available
Cross-References
SwissProt Q8NFJ8
TrEMBL
UniProt Splice Variant
Entrez Gene 27319
UniGene Hs.388788 Hs.591870 Hs.743680
RefSeq NM_152414
HUGO HGNC:11963
OMIM 613483
CCDS CCDS6179
HPRD
IMGT
EMBL AF504925 BK000273
GenPept AAM28881 DAA01053
RNA Seq Atlas 27319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca