InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SH3KBP1

Summary

InnateDB Protein

IDBP-234456.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH3KBP1

Protein Name

SH3-domain kinase binding protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000380921

InnateDB Gene

IDBG-49936 (SH3KBP1)

Protein Structure

UniProt Annotation

Function

Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. {ECO:0000250, ECO:0000269PubMed:11894095, ECO:0000269PubMed:11894096, ECO:0000269PubMed:12177062, ECO:0000269PubMed:12734385, ECO:0000269PubMed:12771190, ECO:0000269PubMed:15090612, ECO:0000269PubMed:15707590, ECO:0000269PubMed:16177060, ECO:0000269PubMed:16256071, ECO:0000269PubMed:21834987}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Also expressed in some cancer cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 306 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	306 [view]
Protein-Protein	304 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0017124	SH3 domain binding

Biological Process

GO:0006897	endocytosis
GO:0006915	apoptotic process
GO:0007010	cytoskeleton organization
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008360	regulation of cell shape
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0030659	cytoplasmic vesicle membrane
GO:0043005	neuron projection
GO:0045202	synapse