InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SH3KBP1

Summary

InnateDB Gene

IDBG-49936.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH3KBP1

Gene Name

SH3-domain kinase binding protein 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000147010

Encoded Proteins

IDBP-49938

SH3-domain kinase binding protein 1

IDBP-49940

SH3-domain kinase binding protein 1

IDBP-49944

SH3-domain kinase binding protein 1

IDBP-49946

SH3-domain kinase binding protein 1

IDBP-234456

SH3-domain kinase binding protein 1

IDBP-364796

SH3-domain kinase binding protein 1

IDBP-364800

SH3-domain kinase binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:19533975-19887601

Strand

Reverse strand

Band

p22.12

Transcripts

ENST00000379726	ENSP00000369049
ENST00000379716	ENSP00000369039
ENST00000379698	ENSP00000369020
ENST00000379697	ENSP00000369019
ENST00000397821	ENSP00000380921
ENST00000432234	ENSP00000388766
ENST00000431164	ENSP00000409292
ENST00000494961
ENST00000477102

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 306 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	306 [view]
Protein-Protein	304 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0017124	SH3 domain binding

Biological Process

GO:0006897	endocytosis
GO:0006915	apoptotic process
GO:0007010	cytoskeleton organization
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008360	regulation of cell shape
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0030659	cytoplasmic vesicle membrane
GO:0043005	neuron projection
GO:0045202	synapse