InnateDB Protein
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IDBP-234566.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLR3D
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Protein Name
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polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
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Synonyms
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BN51T; RPC4; RPC53; TSBN51;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380904
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InnateDB Gene
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IDBG-10695 (POLR3D)
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Protein Structure
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Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
40
[view]
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Protein-Protein |
40
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006383
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transcription from RNA polymerase III promoter
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GO:0006385
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transcription elongation from RNA polymerase III promoter
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GO:0006386
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termination of RNA polymerase III transcription
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GO:0010467
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gene expression
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GO:0032481
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positive regulation of type I interferon production
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GO:0032728
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positive regulation of interferon-beta production
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GO:0045087
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innate immune response
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GO:0045089
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positive regulation of innate immune response
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GO:0051607
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defense response to virus
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Cellular Component |
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PDB ID |
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InterPro |
IPR007811
DNA-directed RNA polymerase III subunit RPC4
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PFAM |
PF05132
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P05423
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PhosphoSite |
PhosphoSite-P05423
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TrEMBL |
E5RHT4
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UniProt Splice Variant |
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Entrez Gene |
661
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UniGene |
Hs.694963
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RefSeq |
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HUGO |
HGNC:1080
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OMIM |
187280
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CCDS |
CCDS34858
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HPRD |
01755
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IMGT |
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EMBL |
AC105206
AF346574
AY092086
BC000516
BC002603
BC003039
BC004484
CH471080
CR536509
CR541803
L15301
M17754
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GenPept |
AAA51838
AAA72377
AAH02603
AAH04484
AAK15371
AAM18216
CAG38747
CAG46602
EAW63689
EAW63690
EAW63691
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