InnateDB Protein
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IDBP-234821.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HOOK2
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Protein Name
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hook homolog 2 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380785
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InnateDB Gene
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IDBG-30950 (HOOK2)
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Protein Structure
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Function |
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. {ECO:0000269PubMed:17140400, ECO:0000269PubMed:17540036, ECO:0000269PubMed:18799622}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
39
[view]
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Protein-Protein |
36
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008636
Hook-related protein family
IPR009060
UBA-like
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PFAM |
PF05622
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96ED9
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PhosphoSite |
PhosphoSite-Q96ED9
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TrEMBL |
K7ENU5
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UniProt Splice Variant |
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Entrez Gene |
29911
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UniGene |
Hs.30792
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RefSeq |
NP_037444
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HUGO |
HGNC:19885
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OMIM |
607824
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CCDS |
CCDS42508
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HPRD |
09698
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IMGT |
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EMBL |
AC018761
AC020934
AF044924
BC012443
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GenPept |
AAC09299
AAH12443
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