Version 5.4
Homo sapiens Gene: HOOK2
Summary
InnateDB Gene IDBG-30950.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOOK2
Gene Name hook homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000095066
Encoded Proteins
IDBP-30952
hook homolog 2 (Drosophila)
IDBP-234821
hook homolog 2 (Drosophila)
IDBP-764538
IDBP-761889
IDBP-762754
IDBP-764914
IDBP-765392
IDBP-761522
IDBP-760456
IDBP-766284
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:12763003-12872740
Strand Reverse strand
Band p13.13
Transcripts
ENST00000264827 ENSP00000264827
ENST00000397668 ENSP00000380785
ENST00000591641
ENST00000589398
ENST00000591251
ENST00000586284
ENST00000586710
ENST00000591839
ENST00000592808
ENST00000589134
ENST00000586188 ENSP00000465091
ENST00000589965
ENST00000592259
ENST00000588052 ENSP00000466497
ENST00000589400 ENSP00000467097
ENST00000587178 ENSP00000465042
ENST00000587964 ENSP00000467739
ENST00000589765
ENST00000589915
ENST00000593143
ENST00000586719 ENSP00000465427
ENST00000590839 ENSP00000466616
ENST00000592079 ENSP00000465023
ENST00000592512
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 36 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006897 endocytosis
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0045022 early endosome to late endosome transport
Cellular Component
GO:0005813 centrosome
GO:0005874 microtubule
GO:0030897 HOPS complex
GO:0070695 FHF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052566
View Gene Order
ENSBTAG00000008654
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.30792
RefSeq NM_001100176 NM_013312 XM_005259873 XM_005259874
HUGO
OMIM
CCDS CCDS42507 CCDS42508
HPRD 09698
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca