InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRF7

Summary

InnateDB Protein

IDBP-235071.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF7

Protein Name

interferon regulatory factor 7

Synonyms

IRF-7H; IRF7A; IRF7B; IRF7C; IRF7H;

Species

Homo sapiens

Ensembl Protein

ENSP00000380700

InnateDB Gene

IDBG-17225 (IRF7)

Protein Structure

UniProt Annotation

Function

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages. {ECO:0000269PubMed:11073981, ECO:0000269PubMed:12374802, ECO:0000269PubMed:15361868, ECO:0000269PubMed:17404045}.

Subcellular Localization

Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.

Disease Associations

Tissue Specificity

Expressed predominantly in spleen, thymus and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 122 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	122 [view]
Protein-Protein	79 [view]
Protein-DNA	43 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0002819	regulation of adaptive immune response
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0009615	response to virus
GO:0019043	establishment of viral latency
GO:0019221	cytokine-mediated signaling pathway
GO:0032479	regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0032607	interferon-alpha production
GO:0032608	interferon-beta production
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0034127	regulation of MyD88-independent toll-like receptor signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0039530	MDA-5 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045655	regulation of monocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050776	regulation of immune response
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:2000110	negative regulation of macrophage apoptotic process