InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSPAN4

Summary

InnateDB Protein

IDBP-235432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSPAN4

Protein Name

tetraspanin 4

Synonyms

NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4;

Species

Homo sapiens

Ensembl Protein

ENSP00000380555

InnateDB Gene

IDBG-235428 (TSPAN4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0005178	integrin binding

Biological Process

GO:0006461

protein complex assembly

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031982	vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000301 Tetraspanin
IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin

PFAM

PF00335

PRINTS

PR00259

PIRSF

PIRSF002419

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O14817

PhosphoSite

PhosphoSite-

TrEMBL

E9PSH3

UniProt Splice Variant

Entrez Gene

7106

UniGene

Hs.691297

RefSeq

NP_001020407

HUGO

HGNC:11859

OMIM

602644

CCDS

CCDS7721

HPRD

04033

IMGT

EMBL

AF022813 AF054841 AK291089 AP006623 BC000389 BC019314 BC093031 BT006776 CH471158 CR457108

GenPept

AAC51864 AAC69717 AAH00389 AAH19314 AAH93031 AAP35422 BAF83778 CAG33389 EAX02409 EAX02410 EAX02411