InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC6A12

Summary

InnateDB Protein

IDBP-235673.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC6A12

Protein Name

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

Synonyms

BGT-1; BGT1; GAT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000380464

InnateDB Gene

IDBG-11214 (SLC6A12)

Protein Structure

UniProt Annotation

Function

Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005332	gamma-aminobutyric acid:sodium symporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006836	neurotransmitter transport
GO:0006865	amino acid transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0015812	gamma-aminobutyric acid transport
GO:0055085	transmembrane transport