Version 5.4
Homo sapiens Gene: SLC6A12
Summary
InnateDB Gene IDBG-11214.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A12
Gene Name solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Synonyms BGT-1; BGT1; GAT2
Species Homo sapiens
Ensembl Gene ENSG00000111181
Encoded Proteins
IDBP-11216
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
IDBP-235673
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
IDBP-360763
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
IDBP-600139
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
IDBP-603780
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
IDBP-584778
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:190077-214570
Strand Reverse strand
Band p13.33
Transcripts
ENST00000359674 ENSP00000352702
ENST00000397296 ENSP00000380464
ENST00000424061 ENSP00000399136
ENST00000545058
ENST00000536824 ENSP00000444268
ENST00000542825
ENST00000535498
ENST00000544782
ENST00000538272
ENST00000540094
ENST00000538580
ENST00000536116
ENST00000537793 ENSP00000439351
ENST00000535347 ENSP00000446082
ENST00000537826
ENST00000538424
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005332 gamma-aminobutyric acid:sodium symporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006836 neurotransmitter transport
GO:0006865 amino acid transport
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0009992 cellular water homeostasis
GO:0010033 response to organic substance
GO:0015812 gamma-aminobutyric acid transport
GO:0055085 transmembrane transport
GO:0071474 cellular hyperosmotic response
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030109
View Gene Order
ENSBTAG00000038415
Not yet available
Pathways
NETPATH
REACTOME
REACT_20506
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_813
Creatine metabolism pathway
REACT_23910
Reuptake of GABA pathway
REACT_23947
GABA synthesis, release, reuptake and degradation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.437174
RefSeq NM_001122847 NM_001122848 NM_001206931 NM_003044 XM_005253746
HUGO
OMIM
CCDS CCDS8501
HPRD 04358
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca