Version 5.4
Homo sapiens Protein: RNF180
Summary
InnateDB Protein IDBP-23598.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF180
Protein Name ring finger protein 180
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000373752
InnateDB Gene IDBG-23596 (RNF180)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031624 ubiquitin conjugating enzyme binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0016567 protein ubiquitination
GO:0030534 adult behavior
GO:0031398 positive regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042415 norepinephrine metabolic process
GO:0042428 serotonin metabolic process
GO:0050790 regulation of catalytic activity
GO:1901360 organic cyclic compound metabolic process
Cellular Component
GO:0005635 nuclear envelope
GO:0016021 integral component of membrane
GO:0031227 intrinsic component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86T96
PhosphoSite PhosphoSite-Q86T96
TrEMBL D6RE88
UniProt Splice Variant
Entrez Gene 285671
UniGene Hs.657843
RefSeq NP_001107033
HUGO HGNC:27752
OMIM
CCDS CCDS47219
HPRD 15263
IMGT
EMBL AC016623 AC092360 AK090756 AL832580 BC101277 BC101278 BC101279 BC101397
GenPept AAI01278 AAI01279 AAI01280 AAI01398 BAC03514 CAD89939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca