Homo sapiens Protein: ATP2A3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-236187.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | ATP2A3 | ||||||||||||||||||
Protein Name | ATPase, Ca++ transporting, ubiquitous | ||||||||||||||||||
Synonyms | SERCA3; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000380229 | ||||||||||||||||||
InnateDB Gene | IDBG-18252 (ATP2A3) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269PubMed:11956212, ECO:0000269PubMed:15028735}. | ||||||||||||||||||
Subcellular Localization | Nucleus membrane {ECO:0000269PubMed:15028735}; Multi-pass membrane protein {ECO:0000269PubMed:15028735}. Endoplasmic reticulum membrane {ECO:0000269PubMed:15028735}; Multi-pass membrane protein {ECO:0000269PubMed:15028735}. Sarcoplasmic reticulum membrane {ECO:0000269PubMed:15028735}; Multi-pass membrane protein {ECO:0000269PubMed:15028735}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines. {ECO:0000269PubMed:11956212, ECO:0000269PubMed:15028735}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR001757
Cation-transporting P-type ATPase IPR004014 Cation-transporting P-type ATPase, N-terminal IPR005782 Calcium-transporting P-type ATPase, subfamily IIA, SERCA-type IPR006068 Cation-transporting P-type ATPase, C-terminal IPR008250 P-type ATPase, A domain IPR023214 HAD-like domain IPR023299 P-type ATPase, cytoplasmic domain N |
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PFAM |
PF00690
PF00689 PF00122 PF00702 PF08282 PF13419 |
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PRINTS |
PR00119
PR00120 |
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PIRSF | |||||||||||||||||||
SMART |
SM00831
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q93084 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q93084 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 489 | ||||||||||||||||||
UniGene | Hs.513870 | ||||||||||||||||||
RefSeq | NP_777618 | ||||||||||||||||||
HUGO | HGNC:813 | ||||||||||||||||||
OMIM | 601929 | ||||||||||||||||||
CCDS | CCDS42234 | ||||||||||||||||||
HPRD | 03568 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC005940 AF068220 AF068221 AF458228 AF458229 AY460339 BC035729 CH471108 S68239 Y15724 Y15725 Y15726 Y15727 Y15728 Y15729 Y15730 Y15737 Y15738 Z69880 Z69881 | ||||||||||||||||||
GenPept | AAB29700 AAC24525 AAC24526 AAH35729 AAL78967 AAL78968 AAR15415 CAA75739 CAA75747 CAA75748 CAA93736 CAA93737 EAW90463 EAW90468 EAW90469 | ||||||||||||||||||