InnateDB Protein
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IDBP-236237.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PEPD
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Protein Name
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peptidase D
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Synonyms
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PROLIDASE;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380226
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InnateDB Gene
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IDBG-42695 (PEPD)
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Protein Structure
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Function |
Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
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Subcellular Localization |
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Disease Associations |
Prolidase deficiency (PD) [MIM:170100]: A multisystem disorder associated with massive iminodipeptiduria and lack of or reduced prolidase activity in erythrocytes, leukocytes, or cultured fibroblasts. Clinical features include skin ulcers, developmental delay, recurrent infections, and a characteristic facies. {ECO:0000269PubMed:12384772, ECO:0000269PubMed:2365824, ECO:0000269PubMed:8198124, ECO:0000269PubMed:8900231}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
33
[view]
|
Protein-Protein |
32
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000994
Peptidase M24, structural domain
IPR007865
Aminopeptidase P, N-terminal
IPR028980
Creatinase/Aminopeptidase P, N-terminal
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PFAM |
PF00557
PF05195
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PRINTS |
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PIRSF |
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SMART |
SM01011
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TIGRFAMs |
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Modification |
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SwissProt |
P12955
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PhosphoSite |
PhosphoSite-P12955
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5184
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UniGene |
Hs.36473
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RefSeq |
NP_001159528
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HUGO |
HGNC:8840
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OMIM |
613230
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CCDS |
CCDS54245
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HPRD |
01358
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IMGT |
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EMBL |
AC008744
AC010485
AK290756
AK290781
AK291561
AK293126
AK294619
BC004305
BC015027
BC028295
BT006692
J04605
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GenPept |
AAA60064
AAH04305
AAH15027
AAH28295
AAP35338
BAF83445
BAF83470
BAF84250
BAG56678
BAG57802
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