InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHOG

Summary

InnateDB Protein

IDBP-236357.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHOG

Protein Name

ras homolog gene family, member G (rho G)

Synonyms

ARHG;

Species

Homo sapiens

Ensembl Protein

ENSP00000380175

InnateDB Gene

IDBG-24680 (RHOG)

Protein Structure

UniProt Annotation

Function

Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269PubMed:15133129, ECO:0000269PubMed:17074883, ECO:0000269PubMed:17875742, ECO:0000269PubMed:20679435}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0015031	protein transport
GO:0016601	Rac protein signal transduction
GO:0030036	actin cytoskeleton organization
GO:0030168	platelet activation
GO:0032863	activation of Rac GTPase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0060326	cell chemotaxis
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt