InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLEC4M

Summary

InnateDB Protein

IDBP-23637.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLEC4M

Protein Name

C-type lectin domain family 4, member M

Synonyms

CD209L; CD299; DC-SIGN2; DC-SIGNR; DCSIGNR; HP10347; L-SIGN; LSIGN;

Species

Homo sapiens

Ensembl Protein

ENSP00000316228

InnateDB Gene

IDBG-23635 (CLEC4M)

Protein Structure

UniProt Annotation

Function

Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus. {ECO:0000269PubMed:11226297, ECO:0000269PubMed:11257134}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.Isoform 2: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.Isoform 3: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.Isoform 5: Secreted {ECO:0000305}.Isoform 6: Secreted {ECO:0000305}.Isoform 7: Secreted {ECO:0000305}.Isoform 10: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells. {ECO:0000269PubMed:11226297, ECO:0000269PubMed:11257134, ECO:0000269PubMed:15496474}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005537	mannose binding
GO:0030246	carbohydrate binding
GO:0030369	ICAM-3 receptor activity
GO:0042605	peptide antigen binding
GO:0046790	virion binding
GO:0046872	metal ion binding

Biological Process

GO:0006897	endocytosis
GO:0007159	leukocyte cell-cell adhesion
GO:0009988	cell-cell recognition
GO:0010468	regulation of gene expression
GO:0019048	modulation by virus of host morphology or physiology
GO:0019062	virion attachment to host cell
GO:0019079	viral genome replication
GO:0019882	antigen processing and presentation
GO:0030193	regulation of blood coagulation
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response
GO:0046968	peptide antigen transport
GO:0075733	intracellular transport of virus