InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAPDH

Summary

InnateDB Protein

IDBP-236491.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAPDH

Protein Name

glyceraldehyde-3-phosphate dehydrogenase

Synonyms

G3PD; GAPD; HEL-S-162eP;

Species

Homo sapiens

Ensembl Protein

ENSP00000380067

InnateDB Gene

IDBG-14270 (GAPDH)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 232 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	232 [view]
Protein-Protein	216 [view]
Protein-DNA	10 [view]
Protein-RNA	6 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0035605	peptidyl-cysteine S-nitrosylase activity
GO:0042802	identical protein binding
GO:0050661	NADP binding
GO:0051287	NAD binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0017148	negative regulation of translation
GO:0035606	peptidyl-cysteine S-trans-nitrosylation
GO:0044281	small molecule metabolic process
GO:0050821	protein stabilization
GO:0051402	neuron apoptotic process
GO:0055114	oxidation-reduction process
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097452	GAIT complex

Protein Structure and Domains

PDB ID

InterPro

IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I
IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain
IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain
IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family

PFAM

PF00044
PF02800

PRINTS

PR00078

PIRSF

PIRSF000149

SMART

SM00846

TIGRFAMs

Post-translational Modifications

Modification

Cross-References