InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRF9

Summary

InnateDB Protein

IDBP-236585.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF9

Protein Name

interferon regulatory factor 9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000380073

InnateDB Gene

IDBG-236583 (IRF9)

Protein Structure

UniProt Annotation

Function

Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11846981}. Nucleus {ECO:0000269PubMed:11846981}. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	31 [view]
Protein-DNA	31 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0019221	cytokine-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045351	type I interferon biosynthetic process
GO:0051607	defense response to virus
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway