InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP4K1

Summary

InnateDB Protein

IDBP-236612.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP4K1

Protein Name

mitogen-activated protein kinase kinase kinase kinase 1

Synonyms

HPK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000380066

InnateDB Gene

IDBG-49296 (MAP4K1)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. {ECO:0000269PubMed:24362026, ECO:0000269PubMed:8824585}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. {ECO:0000269PubMed:8824585}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008349	MAP kinase kinase kinase kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0007257	activation of JUN kinase activity
GO:0008283	cell proliferation
GO:0018105	peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt