InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CENPK

Summary

InnateDB Protein

IDBP-236988.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CENPK

Protein Name

centromere protein K

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379911

InnateDB Gene

IDBG-23981 (CENPK)

Protein Structure

UniProt Annotation

Function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269PubMed:16622420, ECO:0000269PubMed:16716197, ECO:0000269PubMed:18045986}.

Subcellular Localization

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Disease Associations

Note=Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.

Tissue Specificity

Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta. {ECO:0000269PubMed:8950979}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006334	nucleosome assembly
GO:0034080	centromere-specific nucleosome assembly
GO:0045944	positive regulation of transcription from RNA polymerase II promoter