InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADHFE1

Summary

InnateDB Protein

IDBP-237105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADHFE1

Protein Name

alcohol dehydrogenase, iron containing, 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379865

InnateDB Gene

IDBG-23818 (ADHFE1)

Protein Structure

UniProt Annotation

Function

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. {ECO:0000269PubMed:16435184}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Only expressed in adult liver. {ECO:0000269PubMed:12592711}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0047988	hydroxyacid-oxoacid transhydrogenase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0015993	molecular hydrogen transport
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process