Version 5.4
Homo sapiens Gene: ADHFE1
Summary
InnateDB Gene IDBG-23818.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADHFE1
Gene Name alcohol dehydrogenase, iron containing, 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147576
Encoded Proteins
IDBP-23822
alcohol dehydrogenase, iron containing, 1
IDBP-237105
alcohol dehydrogenase, iron containing, 1
IDBP-237107
alcohol dehydrogenase, iron containing, 1
IDBP-371742
alcohol dehydrogenase, iron containing, 1
IDBP-371749
alcohol dehydrogenase, iron containing, 1
IDBP-371770
alcohol dehydrogenase, iron containing, 1
IDBP-371771
alcohol dehydrogenase, iron containing, 1
IDBP-371773
alcohol dehydrogenase, iron containing, 1
IDBP-371777
alcohol dehydrogenase, iron containing, 1
IDBP-371780
alcohol dehydrogenase, iron containing, 1
IDBP-371782
alcohol dehydrogenase, iron containing, 1
IDBP-482120
alcohol dehydrogenase, iron containing, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:66430185-66471601
Strand Forward strand
Band q13.1
Transcripts
ENST00000276576 ENSP00000276576
ENST00000396623 ENSP00000379865
ENST00000396621 ENSP00000379864
ENST00000415254 ENSP00000407115
ENST00000424777 ENSP00000410883
ENST00000426810 ENSP00000406905
ENST00000422166 ENSP00000387956
ENST00000449512 ENSP00000416450
ENST00000431959 ENSP00000392925
ENST00000443372 ENSP00000409714
ENST00000419955 ENSP00000392040
ENST00000523113 ENSP00000428055
ENST00000496501
ENST00000466920
ENST00000463261
ENST00000518781
ENST00000480040
ENST00000466739
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0047988 hydroxyacid-oxoacid transhydrogenase activity
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0015993 molecular hydrogen transport
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025911
View Gene Order
ENSBTAG00000004476
Not yet available
Pathways
NETPATH
REACTOME
REACT_25367
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
INOH website
Tyrosine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F2Z2N0
UniProt Splice Variant
Entrez Gene 137872
UniGene Hs.720023
RefSeq NM_144650
HUGO HGNC:16354
OMIM 611083
CCDS CCDS6190
HPRD 12428
IMGT
EMBL AC009879
GenPept
RNA Seq Atlas 137872

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca