InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPS2

Summary

InnateDB Protein

IDBP-237149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPS2

Protein Name

G protein pathway suppressor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379841

InnateDB Gene

IDBG-24467 (GPS2)

Protein Structure

UniProt Annotation

Function

Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:8943324}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	54 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005095	GTPase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000188	inactivation of MAPK activity
GO:0007049	cell cycle
GO:0007254	JNK cascade
GO:0046329	negative regulation of JNK cascade