InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC30A5

Summary

InnateDB Protein

IDBP-237169.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC30A5

Protein Name

solute carrier family 30 (zinc transporter), member 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379836

InnateDB Gene

IDBG-25156 (SLC30A5)

Protein Structure

UniProt Annotation

Function

Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP. {ECO:0000269PubMed:11904301, ECO:0000269PubMed:11937503, ECO:0000269PubMed:15276077, ECO:0000269PubMed:15525635, ECO:0000269PubMed:15994300}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:11904301, ECO:0000269PubMed:11937503, ECO:0000269PubMed:15525635}; Multi- pass membrane protein {ECO:0000269PubMed:11904301, ECO:0000269PubMed:11937503, ECO:0000269PubMed:15525635}. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin- containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells. {ECO:0000269PubMed:11904301, ECO:0000269PubMed:11937503}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005385	zinc ion transmembrane transporter activity
GO:0008270	zinc ion binding
GO:0008324	cation transmembrane transporter activity

Biological Process

GO:0006812	cation transport
GO:0006824	cobalt ion transport
GO:0006829	zinc ion transport
GO:0006882	cellular zinc ion homeostasis
GO:0010043	response to zinc ion
GO:0010155	regulation of proton transport
GO:0044267	cellular protein metabolic process
GO:0055085	transmembrane transport
GO:0071577	zinc ion transmembrane transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030141	secretory granule
GO:0030667	secretory granule membrane